ResistanceProof Oncology Built on Conserved Stress Epitopes.
Sutra AI identifies the "Achilles’ heels" of cancer—evolutionarily locked stress epitopes that tumors cannot mutate without catastrophic self-damage.
Overview / Platform Science
What Sutra™ does — Traditional oncology targets mutable oncogenes that inevitably lead to resistance. Sutra™ shifts the paradigm by targeting immutable "stress epitopes"—surface-exposed protein motifs that cancer cells must express to survive the harsh, hypoxic, and acidic conditions of the tumor core.
The 4-Tier Discovery Engine
Our proprietary pipeline filters billions of data points to identify lead candidates:
Transcriptomic "Stress" Signal
Isolates "Hypoxia-High" signatures distinct from normal tissue.
Proteogenomic Surface Validation
Ensures the target is physically exposed on the cell membrane.
Evolutionary Conservation Analysis
Simulates "viral conservation" to find motifs with Entropy bits.
Structural Accessibility
Uses AlphaFold-Multimer to confirm the epitope is stable and accessible to antibodies.
Safety & Biological Fault Tolerance
- 54Tissue Safety Screening — short explainer and visual heatmap examples.
- Safety architecture — off-target risk mitigation, biomarker gating strategy, and nonclinical safety endpoints
Lead Programs & Pipeline
ADNPDAC01 Our lead candidate applies two independent biological gates so that cytotoxic payload is released only inside the deep tumor core — protecting healthy tissue while delivering a lethal dose precisely where resistance lives
The Double-Gate Safety Architecture
To address the classic challenge of “on-target, off-tumor” toxicity, Sutra-designed antibody-drug conjugates activate only when two independent biological conditions are satisfied.
Gate 1 — The Epitope
The antibody binds exclusively to a conserved stress epitope that becomes uniquely exposed or strongly upregulated under hypoxic tumor conditions.
Gate 2 — The Linke
The cytotoxic payload is released only when a hypoxia-activated linker senses the extreme oxygen deprivation of the tumor core.
This “AND-Gate” logic ensures that healthy tissues — even those located in mildly hypoxic environments such as the renal medulla — remain unaffected.
Adnexus Biotechnology's platform
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